Think melatonin is safe? New research reveals a hidden heart risk

Long-Term Melatonin Use May Pose Heart Risks

Using melatonin supplements over extended periods to address sleep issues could carry unrecognized cardiac dangers. Research indicates that chronic melatonin users had nearly double the risk of death and were 3.5 times more likely to be hospitalized for heart failure.

Study Findings Presented at AHA 2025

A preliminary study shared at the American Heart Association's Scientific Sessions 2025 revealed adults with persistent insomnia taking melatonin for one year or more showed higher chances of developing heart failure, hospitalization due to heart failure, and increased mortality from any cause, compared to those not using melatonin.

The study results were part of discussions at the AHA's annual conference held from November 7–10 in New Orleans, a premier event for cardiovascular research.

Understanding Melatonin

Melatonin is a hormone produced by the pineal gland that controls the sleep-wake cycle, rising during darkness and falling in daylight. Synthetic melatonin, identical to the natural hormone, is widely used to manage insomnia and jet lag.

In many countries including the United States, melatonin is available over the counter. However, as supplements are not regulated by U.S. authorities, their purity and dosage can vary significantly.

“Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement.”

Experts now advise caution regarding long-term melatonin use despite its reputation as a safe remedy.

Summary

While melatonin is widely seen as safe, new research highlights potential serious heart risks from prolonged use, urging careful consideration before chronic supplementation.

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ScienceDaily ScienceDaily — 2025-11-05

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